Erythrocyte Acetylcholinesterase-Inhibitory Activity of Porphyrin Compounds
نویسندگان
چکیده
Acetylcholinesterase (AChE) inhibition is important because of its health-related implications. Three porphyrin derivatives, Tetraphenylporphinesulfonate (TPPS), 5, 10, 15, 20-Tetrakis (4sulfonatophenyl) porphyrinato Iron (III) Chloride (FeTPPS) and 5, 10, 15, 20-Tetrakis (4-sulfonatophenyl) porphyrinato Iron (III) nitrosyl Chloride (FeNOTPPS), were tested by Molecular Docking as inhibitors of human Acetylcholinesterase enzyme in erythrocyte membrane (AChEH). These compounds can bind to AChEH and can result in reversible inhibition. The experimentally observed docking (activity) pattern in terms of stability of binding to AChEH was found to be: TPPS > FeTPPS > FeNOTPPS. This result demonstrated that binding affinity of these compounds to AChEH does not increase with the increase in hydrophobicity of these molecules.
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